General Information

  • ID:  hor001107
  • Uniprot ID:  Q9DGD4
  • Protein name:  Gonadotropin-inhibitory hormone
  • Gene name:  GNIH
  • Organism:  Coturnix japonica (Japanese quail) (Coturnix coturnix japonica)
  • Family:  FARP (FMRFamide related peptide) family
  • Source:  animal
  • Expression:  Specifically expressed in the diencephalon.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Coturnix (genus), Perdicinae (subfamily), Phasianidae (family), Galliformes (order), Galloanserae (superorder), Neognathae (infraclass), Aves (class), Coelurosauria, Theropoda, Saurischia, Dinosauria, Archosauria, Archelosauria, Sauria, Sauropsida, Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  SIKPSAYLPLRF
  • Length:  12
  • Propeptide:  MEIISTQKFILLTLATVAFLTPHGACLDELMKSSLESREDDDDKYYETKDSILEEKQRSLNFEEMKDWGSKNFMKVNTPTVNKVPNSVANLPLRFGRSNPEERSIKPSAYLPLRFGRAFGESLSRRAPNLSNRSGRSPLARSSIQSLLNLSQRFGKSVPISLSQGVQESEPGM
  • Signal peptide:  MEIISTQKFILLTLATVAFLTPHGAC
  • Modification:  T12 Phenylalanine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Directly inhibit gonadotropin synthesis;regulate reproduction of vertebrates by directly modulating GnRH-I and GnRH-II neuronal activity, in addition to influencing the pituitary gland.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-Q9DGD4-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor001107_AF2.pdbhor001107_ESM.pdb

Physical Information

Mass: 158805 Formula: C67H106N16O16
Absent amino acids: CDEGHMNQTVW Common amino acids: LPS
pI: 10.45 Basic residues: 2
Polar residues: 3 Hydrophobic residues: 5
Hydrophobicity: 18.33 Boman Index: -786
Half-Life: 1.9 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 105.83
Instability Index: 4395.83 Extinction Coefficient cystines: 1490
Absorbance 280nm: 135.45

Literature

  • PubMed ID:  17901228
  • Title:  Gonadotropin-inhibitory Hormone Neurons Interact Directly With Gonadotropin-Releasing hormone-I and -II Neurons in European Starling Brain